Yellen's group is interested in developing highly parallel mechanisms for controlling the transport and assembly of ensembles of objects ranging from micron-sized colloidal particles to single cells. As of 2013, Professor Yellen is active in two main areas of research:
1) Development of single cell analysis tools using magnetic circuits. The goal of this project is to develop an automated single cell analysis platform that allows for highly flexible and highly parallel manipulation of single cells. Our approach draws inspiration from electronic circuit theory through the development highly flexible methods for transporting particles above magnetic thin film patterns either reversibly (conductor) or irreversibly (rectifier), storing cells in well-defined regions of space either temporarily (capacitor) or permanently (data storage), switching current pathways at selected junctions (transistor) and coordinating a large set of electronic functions with few input wires (multiplexer). When combined with microfluidic systems that allow for repeated doses of pharmaceuticals, we will have a developed a platform that is ripe to have a major impact on the field of HIV eradication and cancer suppression.
2) Multiparticle assembly of colloidal crystals. The goal of this project is to understand the formation and phase transitions occuring inside single crystals composed of alloys of colloidal particles. Here, we are interested in observing crystals forming from magnetic and non-magnetic colloidal particles dispersed inside ferrofluid. We are just beginning to solve the questions of how to grow large single crystals, and how to transform these crystals by tilting of an external magnetic field. The results of this project will serve as useful models for understanding how crystals form and transform in the corollary atomic scale materials in nature.
Education
- Ph.D. Drexel University, 2004
Research Interests
Development of single cell analysis tools using magnetic circuits, and multiparticle assembly of colloidal crystals
Representative Publications
- Yellen, BB; Zawistowski, JS; Czech, EA; Sanford, CI; SoRelle, ED; Luftig, MA; Forbes, ZG; Wood, KC; Hammerbacher, J, Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses., Science Advances, vol 7 no. 38 (2021) [10.1126/sciadv.abf9840] [abs].
- Li, L; Shields, CW; Huang, J; Zhang, Y; Ohiri, KA; Yellen, BB; Chilkoti, A; López, GP, Rapid capture of biomolecules from blood via stimuli-responsive elastomeric particles for acoustofluidic separation., The Analyst, vol 145 no. 24 (2021), pp. 8087-8096 [10.1039/d0an01164a] [abs].
- Li, Y; Motschman, JD; Kelly, ST; Yellen, BB, Injection Molded Microfluidics for Establishing High-Density Single Cell Arrays in an Open Hydrogel Format., Analytical Chemistry, vol 92 no. 3 (2020), pp. 2794-2801 [10.1021/acs.analchem.9b05099] [abs].
- Ohiri, KA; Kelly, ST; Motschman, JD; Lin, KH; Wood, KC; Yellen, BB, An acoustofluidic trap and transfer approach for organizing a high density single cell array., Lab Chip, vol 18 no. 14 (2018), pp. 2124-2133 [10.1039/c8lc00196k] [abs].
- Pham, AT; Zhuang, Y; Detwiler, P; Socolar, JES; Charbonneau, P; Yellen, BB, Phase diagram and aggregation dynamics of a monolayer of paramagnetic colloids., Physical Review. E, vol 95 no. 5-1 (2017) [10.1103/physreve.95.052607] [abs].